In Vitro Anthelmintic Activity of Some 1-Substituted Imidazole Derivatives

Anthelmintic resistance creates a major hitch over the decades throughout the world. As per WHO only few drugs are frequently used in the treatment of helminth infestations in human beings. In view of this, an attempt has been made to study the anthelmintic activity of some newly synthesized 1-substituted imidazoles (1a-1d, 2a-2d) were synthesized and characterized by their spectral data. All the prototypes were examined for their anthelmintic activity against african earthworms Eudrilus eugeniae at various concentrations (5, 10 and 20 mg/ml). Each prototype was tested for their onset of paralysis time followed by time of death of worms. All the prototypes were found not only paralyze (vermifuge) but also to kill the earthworms (vermicidal). All prototypes at the concentration of 20 mg/ml were shown significant activity (P<0.01) with that of control. The bromo substituted phenacyl imidazoles (1b and 2b), phenyl substituted phenacyl imidazoles (1c and 2c) and nitro substituted phenacyl imidazoles (1d and 2d) were found to be comparable to that of the reference standards albendazole and piperazine citrate (20 mg/ml).